Adult Mouse Retina Explants: From ex vivo to in vivo Model of Central Nervous System Injuries.

ABSTRACT: In mammals, adult neurons fail to regenerate following any insult to adult central nervous system (CNS), which leads to a permanent and irreversible loss of motor and cognitive functions. For a long time, much effort has been deployed to uncover mechanisms of axon regeneration in the CNS. Even if some cases of functional recovery have been reported, there is still a discrepancy regarding the functionality of a neuronal circuit upon lesion. Today, there is a need not only to identify new molecules implicated in adult CNS axon regeneration, but also to decipher the fine molecular mechanisms associated with regeneration failure. Here, we propose to use cultures of adult retina explants to study all molecular and cellular mechanisms that occur during CNS regeneration. We show that adult retina

SUBMITTER: Schaeffer J 

PROVIDER: S-EPMC7723849 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature