Screening the CALIBR ReFRAME Library in Search for Inhibitors of Candida auris Biofilm Formation.

ABSTRACT: Candida auris is an emerging yeast which, since its first isolation about a decade ago, has spread rapidly and triggered major infectious outbreaks in health care facilities around the world. C. auris strains often display resistance to clinically-used antifungal agents, contributing to high mortality rates. Thus, there is an urgent need for new antifungals to contain the spread of this emerging multi-drug resistant pathogen and to improve patient outcomes. However, the timeline for the development of a new antifungal agent typically exceeds 10‑15 years. Thus, repurposing of current drugs could significantly accelerate the development and eventual deployment of novel therapies for the treatment of C. auris infections. Toward this end, in this study we have profiled a l

SUBMITTER: Wall G 

PROVIDER: S-EPMC7723901 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature