Platelets Selectively Regulate the Release of BDNF, But Not That of Its Precursor Protein, proBDNF.

ABSTRACT:

Background

Brain-derived neurotrophic factor (BDNF) plays a role in synaptic plasticity and neuroprotection. BDNF has well-established pro-survival effects, whereas its precursor protein, proBDNF, induces apoptosis. Thus, it has been suggested that the proBDNF/BDNF ratio could be an indicator of neuronal health. Access to neurons is, understandably, limited. Because of their similarities, platelets have been put forward as a non-invasive biomarker of neuronal health; indeed, they store large quantities of BDNF and can release it into circulation upon activation, similarly to neurons. However, whether platelets also express the precursor proBDNF protein remains unknown. We therefore sought to characterize proBDNF levels in human platelets and plasma.

Methods

The presence of p

SUBMITTER: Le Blanc J 

PROVIDER: S-EPMC7723927 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature