SUMMER, a shiny utility for metabolomics and multiomics exploratory research.

ABSTRACT:

Introduction

Cellular metabolites are generated by a complex network of biochemical reactions. This makes interpreting changes in metabolites exceptionally challenging.

Objectives

To develop a computational tool that integrates multiomics data at the level of reactions.

Methods

Changes in metabolic reactions are modeled with input from transcriptomics/proteomics measurements of enzymes and metabolomic measurements of metabolites.

Results

We developed SUMMER, which identified more relevant signals, key metabolic reactions, and relevant underlying biological pathways in a real-world case study.

Conclusion

SUMMER performs integrative analysis for data interpretation and exploration. SUMMER is freely accessible at http://summer.salk.edu and the code is avail

SUBMITTER: Huang L 

PROVIDER: S-EPMC7723939 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature