The Molecular and Microenvironmental Landscape of Glioblastomas: Implications for the Novel Treatment Choices.

ABSTRACT: Glioblastoma (GBM) is the most frequent and aggressive primary central nervous system tumor. Surgery followed by radiotherapy and chemotherapy with alkylating agents constitutes standard first-line treatment of GBM. Complete resection of the GBM tumors is generally not possible given its high invasive features. Although this combination therapy can prolong survival, the prognosis is still poor due to several factors including chemoresistance. In recent years, a comprehensive characterization of the GBM-associated molecular signature has been performed. This has allowed the possibility to introduce a more personalized therapeutic approach for GBM, in which novel targeted therapies, including those employing tyrosine kinase inhibitors (TKIs), could be employed. The GBM tumor microenvironment

SUBMITTER: Di Cintio F 

PROVIDER: S-EPMC7724040 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature