Prediction of Postoperative Ileus in Patients With Colorectal Cancer by Preoperative Gut Microbiota.

ABSTRACT:

Background

Ileus and postoperative ileus (POI) are common complications of colorectal cancer (CRC). However, little is known about the gut microbiota associated with ileus.

Method

Differences in gut microbiota were evaluated by 16S rRNA gene sequencing. We characterized the gut microbiota in 85 CRC patients (cohort 1) and detected differences, and an independent cohort composed of 38 CRC patients (cohort 2) was used to evaluate the results.

Results

The gut microbiota of CRC patients with and without ileus exhibited large differences in alpha- and beta-diversities and bacterial taxa. The Firmicutes-to-Bacteroidetes ratio and microbial dysbiosis index (MDI) showed greater dysbiosis among ileus patients than among those without ileus. According to the location of CRC, th

SUBMITTER: Jin Y 

PROVIDER: S-EPMC7724052 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature