Efficacy and safety of dronedarone by atrial fibrillation history duration: Insights from the ATHENA study.

ABSTRACT:

Background

Atrial fibrillation/atrial flutter (AF/AFL) burden increases with increasing duration of AF/AFL history.

Hypothesis

Outcomes with dronedarone may also be impacted by duration of AF/AFL history.

Methods

In this post hoc analysis of ATHENA, efficacy and safety of dronedarone vs placebo were assessed in groups categorized by time from first known AF/AFL episode to randomization (ie, duration of AF/AFL history): <3 months (short), 3 to <24 months (intermediate), and ≥ 24 months (long).

Results

Of 2859 patients with data on duration of AF/AFL history, 45.3%, 29.6%, and 25.1% had short, intermediate, and long histories, respectively. Patients in the long history group had the highest prevalence of structural heart disease and were more likely to be in AF/A

SUBMITTER: Blomstrom-Lundqvist C 

PROVIDER: S-EPMC7724236 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature