Neurofilament light chain level in plasma extracellular vesicles and Parkinson's disease.

ABSTRACT:

Background

Neurofilament light chain (NfL) is essential for axonal maintenance and reflects neuronal damage. Extracellular vesicles (EVs), especially exosomes, secreted by cells into the blood, are emerging as novel biomedical research platforms of physiological and pathological processes. The present study investigated the possible association between plasma EV NfL and Parkinson's disease (PD).

Methods

One hundred and sixteen patients with mild to moderate PD and 46 non-PD, neurological controls were recruited, and their clinical motor symptoms and cognitive function were evaluated. Plasma EVs were isolated using an exoEasy kit, and immunomagnetic reduction assay was used to assess EV NfL level. Statistical analysis was performed using SPSS 25.0, and p < 0.05 was con

SUBMITTER: Chung CC 

PROVIDER: S-EPMC7724268 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature