A pilot study treatment of malignant tumors using low-dose ¹⁸F-fluorodeoxyglucose (¹⁸F-FDG).

ABSTRACT: Photons, electrons and protons have therapeutic use however positrons have only been used for diagnostic imaging purposes. The energies of positrons (β⁺) from F-18 (0.633 MeV) and electrons (β^-) from I-131 (0.606 MeV) are very close and have similar equilibrium dose constants. Since [¹⁸F]-fluorodeoxyglucose (¹⁸F-FDG) clears rapidly from circulation, administration of 37-74 GBq (1-2 Ci) of ¹⁸F-FDG is relatively safe from an internal radiation dosimetry point of view. We initiated a phase I dose escalation study to assess the safety, toxicity, and potential therapeutic utility of administering 100-200 mCi/m^{2 18}F-FDG delivered over a 1 to 5 day period in patients with advanced lymphomas and solid tumors refractory to

SUBMITTER: Paul DM 

PROVIDER: S-EPMC7724279 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature