Geographic and intra-racial disparities in early-onset colorectal cancer in the SEER 18 registries of the United States.

ABSTRACT:

Background

Although early-onset colorectal cancer (EOCRC) incidence rates (IRs) are increasing, geographic and intra-racial IR disparities are not well defined.

Methods

2000-2015 Surveillance, Epidemiology, and End Results (SEER) program CRC IR Analysis (170,434 cases) was performed from ages 30 to 60 in four US regions, 18 individual registries, metropolitan and nonmetropolitan locations and stratified by race. Analyses were conducted in 1-year and 5-year age increments.

Results

Wide US regional EOCRC IR variations exist: For example, age 45 IRs in the south are 26.8/100,000, 36.0% higher than the West, 19.7/100,000 (p < 0.0001). Disparities magnify between individual registries: EOCRC IRs in highest risk registries were 177-348% (Alaska Natives), 75-200% (Hawaii), 7

SUBMITTER: Abualkhair WH 

PROVIDER: S-EPMC7724480 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature