Ontology highlight
ABSTRACT:
SUBMITTER: Fioriniello S
PROVIDER: S-EPMC7724518 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Fioriniello Salvatore S Csukonyi Eva E Marano Domenico D Brancaccio Arianna A Madonna Michele M Zarrillo Carmela C Romano Alessia A Marracino Federico F Matarazzo Maria R MR D'Esposito Maurizio M Della Ragione Floriana F
Stem cell reports 20201201 6
Methyl-CpG binding protein 2 (MeCP2) has historically been linked to heterochromatin organization, and in mouse cells it accumulates at pericentric heterochromatin (PCH), closely following major satellite (MajSat) DNA distribution. However, little is known about the specific function of MeCP2 in these regions. We describe the first evidence of a role in neurons for MeCP2 and MajSat forward (MajSat-fw) RNA in reciprocal targeting to PCH through their physical interaction. Moreover, MeCP2 contribu ...[more]