Reduced Lymphatic Reserve in Heart Failure With Preserved Ejection Fraction.

ABSTRACT:

Background

Microvascular dysfunction plays an important role in the pathogenesis of heart failure with preserved ejection fraction (HFpEF). However, no mechanistic link between systemic microvasculature and congestion, a central feature of the syndrome, has yet been investigated.

Objectives

This study aimed to investigate capillary-interstitium fluid exchange in HFpEF, including lymphatic drainage and the potential osmotic forces exerted by any hypertonic tissue Na⁺ excess.

Methods

Patients with HFpEF and healthy control subjects of similar age and sex distributions (n = 16 per group) underwent: 1) a skin biopsy for vascular immunohistochemistry, gene expression, and chemical (water, Na⁺, and K⁺) analyses; and 2) venous occlusion pleth

SUBMITTER: Rossitto G 

PROVIDER: S-EPMC7724570 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature