Positive association between dietary acid load and future insulin resistance risk: findings from the Korean Genome and Epidemiology Study.

ABSTRACT:

Background

Acid-base homeostasis is increasingly being recognized to play an important role in normal metabolic function. However, prospective studies on the relationship between diet-induced acid-base imbalance and insulin resistance among Asian populations have been limited. Thus, we investigated whether diet-induced metabolic acidosis was prospectively associated with insulin resistance risk in middle-aged and older Korean adults.

Methods

In total, 5406 participants from the Korean Genome and Epidemiology Study without type 2 diabetes, insulin resistance, cancer, or renal diseases at baseline examination were included in this study. To estimate diet-induced metabolic acidosis, we used potential renal acid load (PRAL) and net endogenous acid production (NEAP) scores calcul

SUBMITTER: Lee KW 

PROVIDER: S-EPMC7724722 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature