A quantitative proteomics analysis for small molecule Stemazole's effect on human neural stem cells.

ABSTRACT:

Background

Stemazole is a novel small molecule that has been suggested to have the ability to protect multiple stem cells. The proliferation-promoting activity and promising neuroprotective effects of stemazole make it a prospective drug for neurodegenerative disease treatment.

Methods

Since previous studies have shown that it protective effect in extreme conditions, to understand more aspects of stemazole, in this study, a systematic tandem mass tags (TMT)-labelled proteomics approach was used to address the whole proteome expression profile with or without stemazole in normal conditions instead of extreme conditions. Bioinformatics analyses, including Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment and protein-protein interaction (PPI)

SUBMITTER: Li H 

PROVIDER: S-EPMC7724819 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature