Mitochondrial DNAs provide insight into trypanosome phylogeny and molecular evolution.

ABSTRACT:

Background

Trypanosomes are single-celled eukaryotic parasites characterised by the unique biology of their mitochondrial DNA. African livestock trypanosomes impose a major burden on agriculture across sub-Saharan Africa, but are poorly understood compared to those that cause sleeping sickness and Chagas disease in humans. Here we explore the potential of the maxicircle, a component of trypanosome mitochondrial DNA to study the evolutionary history of trypanosomes.

Results

We used long-read sequencing to completely assemble maxicircle mitochondrial DNA from four previously uncharacterized African trypanosomes, and leveraged these assemblies to scaffold and assemble a further 103 trypanosome maxicircle gene coding regions from published short-read data. While synteny was larg

SUBMITTER: Kay C 

PROVIDER: S-EPMC7724854 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature