Impact of a 2-year trial of nutritional ketosis on indices of cardiovascular disease risk in patients with type 2 diabetes.

ABSTRACT:

Background

We have previously reported that in patients with type 2 diabetes (T2D) consumption of a very low carbohydrate diet capable of inducing nutritional ketosis over 2 years (continuous care intervention, CCI) resulted in improved body weight, glycemic control, and multiple risk factors for cardiovascular disease (CVD) with the exception of an increase in low density lipoprotein cholesterol (LDL-C). In the present study, we report the impact of this intervention on markers of risk for atherosclerotic cardiovascular disease (CVD), with a focus on lipoprotein subfraction particle concentrations as well as carotid-artery intima-media thickness (CIMT).

Methods

Analyses were performed in patients with T2D who completed 2 years of this study (CCI; n = 194; usual care (UC): n

SUBMITTER: Athinarayanan SJ 

PROVIDER: S-EPMC7724865 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature