Clinical predictors of multiple failure to biological therapy in patients with rheumatoid arthritis.

ABSTRACT:

Background

Biological therapies have improved the clinical course and quality of life of rheumatoid arthritis (RA) patients. Despite the availability and effectiveness of these treatments, some patients experience multiple failures to biologic disease-modifying antirheumatic drugs (bDMARDs), constituting a particular challenge to clinicians.

Objectives

This study aims to determine the percentage of rheumatoid arthritis (RA) patients who fail to respond to subsequent bDMARDs, describe their characteristics, and identify specific baseline and early features during the first bDMARD as possible predictors of consecutive multiple bDMARD failure.

Methods

This is a longitudinal study involving RA patients from the prospective biological cohort drawn from the La Paz Universit

SUBMITTER: Novella-Navarro M 

PROVIDER: S-EPMC7724866 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature