Clinical evaluation of commercial automated SARS-CoV-2 immunoassays.

ABSTRACT:

Objective

Numerous immunoassays for detecting antibodies directed against SARS-CoV-2 have been rapidly developed and released. Validations of these have been performed with a limited number of samples. The lack of standardisation might lead to significantly different results. This study compared ten automated assays from six vendors in terms of sensitivity, specificity and reproducibility.

Methods

This study compared ten fully automated immunoassays from the following vendors: Diasorin, Epitope Diagnostics, Euroimmun, Roche, YHLO, and Snibe. The retrospective part of the study included patients with a laboratory-confirmed COVID-19 infection, and controls comprised patients with a suspected infection, in whom the disease was excluded. Furthermore, biobanked sera were taken as

SUBMITTER: Kittel M 

PROVIDER: S-EPMC7725057 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature