Association of physical activity and sedentary behavior with type 2 diabetes and glycemic traits: a two-sample Mendelian randomization study.

ABSTRACT:

Introduction

Observational studies suggest that physical activity lowers and sedentary behavior increases the risk of type 2 diabetes. Despite of some supportive trial data for physical activity, it is largely unresolved whether these relations are causal or due to bias.

Objective

We investigated the associations between accelerometer-based physical activity and sedentary behavior with type 2 diabetes and several glycemic traits using two-sample Mendelian randomization analysis.

Research design and methods

Single nucleotide polymorphisms (SNPs) associated at p<5×10^-8 with accelerometer-based physical activity average accelerations, vigorous physical activity (fraction of accelerations >425 milligravities), and sedentary behavior (metabolic equivalent task ≤

SUBMITTER: Meisinger C 

PROVIDER: S-EPMC7725078 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature