Profiling Analysis Reveals the Crucial Role of the Endogenous Peptides in Bladder Cancer Progression.

ABSTRACT:

Background

Peptide drugs provide promising regimes in bladder cancer. In order to identify potential bioactive peptides involved in bladder cancer, we performed the present study.

Methods

Liquid chromatography/mass spectrometry assay was used to compare the endogenous peptides between bladder cancer and normal control. The potential biological functions of these dysregulated peptides are assessed by GO analysis and KEGG pathway analysis of their precursors. The SMART and UniProt databases are used to identify the sequences of the dysregulated peptides located in the functional domains. The Open Targets Platform database was used to investigate the precursors related to metabolic diseases.

Results

A total of 9 up-regulated peptides and 110 down-regulated peptides in bl

SUBMITTER: Li W 

PROVIDER: S-EPMC7725083 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature