Acute ethanol exposure rapidly alters cerebellar and cortical microglial physiology.

ABSTRACT: Alcohol use is highly prevalent in modern society and ramifications of alcohol abuse pose a large public health concern. Previous work investigating the effects of alcohol exposure on the brain has implicated microglia, the resident immune cells of the central nervous system (CNS), as critical participants in the brain's response to chronic and developmental ethanol (EtOH) exposure. As rapid sensors of their environment, microglia also have the capacity to rapidly respond to alcohol administration and to contribute to acute effects of alcohol on the brain; however, their acute responses have not been assessed. Here, for the first time, we have examined the acute response of microglia to alcohol intoxication in vivo utilizing two-photon microscopy to assess the dynamics of these motile cell

SUBMITTER: Stowell RD 

PROVIDER: S-EPMC7725224 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature