Interactions between FGF23 and Genotype in Autosomal Dominant Polycystic Kidney Disease.

ABSTRACT:

Background

Higher serum intact fibroblast growth factor 23 (iFGF23) was associated with disease progression in participants with autosomal dominant polycystic kidney disease (ADPKD) in the HALT-PKD Studies. PKD mutation is also an important determinant of progression. We hypothesized that serum levels of iFGF23 and vitamin D metabolites (1,25-dihydroxyvitamin D [1,25(OH)₂D] and 25-hydroxyvitamin D [25[OH]D]) differ according to ADPKD mutation and differentially predict clinical end points according to genotype (significant interaction between genotype and mineral metabolites).

Methods

A total of 864 individuals with ADPKD who participated in the HALT-PKD Study A or B and had measurements of mineral metabolites (1,25[OH]₂D, 25[OH]D, iFGF23) were categori

SUBMITTER: Grau L 

PROVIDER: S-EPMC7725226 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature