Enhancing Collagen Mineralization with Amelogenin Peptide: Towards the Restoration of Dentin.

ABSTRACT: Mammalian teeth primarily consist of two distinct calcified tissues, enamel and dentin, that are intricately integrated by a complex and critical structure, the dentin-enamel junction (DEJ). Loss of enamel exposes the underlying dentin, increasing the risk of several irreversible dental diseases. This paper highlights the significance of utilizing the functional domains of a major enamel matrix protein, amelogenin, intrinsic to tooth enamel and the DEJ interface, to rationally design smaller bioinspired peptides for regeneration of tooth microstructures. Using this strategy, we designed a synthetic peptide, P26, that demonstrates a remarkable dual mineralization potential to restore incipient enamel decay and mineralization defects localized in peripheral dentin below the DEJ. As a proof o

SUBMITTER: Mukherjee K 

PROVIDER: S-EPMC7725229 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature