Ultrasound enhanced synthetic platelet therapy for augmented wound repair.

ABSTRACT: Native platelets perform a number of functions within the wound healing process, including interacting with fibrin fibers at the wound site to bring about retraction after clot formation. Clot retraction improves clot stability and enhances the function of the fibrin network as a provisional matrix to support cellular infiltration of the wound site, thus facilitating tissue repair and remodeling after hemostasis. In cases of traumatic injury or disease, platelets can become depleted and this process disrupted. To that end, our lab has developed synthetic platelet-like particles (PLPs) that recapitulate the clot retraction abilities of native platelets through a Brownian-wrench driven mechanism that drives fibrin network densification and clot retraction over time, however, this Brownian-mo

SUBMITTER: Nandi S 

PROVIDER: S-EPMC7725264 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature