Genetic Control of Radical Cross-linking in a Semisynthetic Hydrogel.

ABSTRACT: Enhancing materials with the qualities of living systems, including sensing, computation, and adaptation, is an important challenge in designing next-generation technologies. Living materials address this challenge by incorporating live cells as actuating components that control material function. For abiotic materials, this requires new methods that couple genetic and metabolic processes to material properties. Toward this goal, we demonstrate that extracellular electron transfer (EET) from Shewanella oneidensis can be leveraged to control radical cross-linking of a methacrylate-functionalized hyaluronic acid hydrogel. Cross-linking rates and hydrogel mechanics, specifically storage modulus, were dependent on various chemical and biological factors, including S. oneidensis g

SUBMITTER: Graham AJ 

PROVIDER: S-EPMC7725273 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature