Ancestral state reconstruction of metabolic pathways across pangenome ensembles.

ABSTRACT: As genome sequencing efforts are unveiling the genetic diversity of the biosphere with an unprecedented speed, there is a need to accurately describe the structural and functional properties of groups of extant species whose genomes have been sequenced, as well as their inferred ancestors, at any given taxonomic level of their phylogeny. Elaborate approaches for the reconstruction of ancestral states at the sequence level have been developed, subsequently augmented by methods based on gene content. While these approaches of sequence or gene-content reconstruction have been successfully deployed, there has been less progress on the explicit inference of functional properties of ancestral genomes, in terms of metabolic pathways and other cellular processes. Herein, we describe PathTrace, an

SUBMITTER: Psomopoulos FE 

PROVIDER: S-EPMC7725326 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature