Comprehensive screening of genomic and metagenomic data reveals a large diversity of tetracycline resistance genes.

ABSTRACT: Tetracyclines are broad-spectrum antibiotics used to prevent or treat a variety of bacterial infections. Resistance is often mediated through mobile resistance genes, which encode one of the three main mechanisms: active efflux, ribosomal target protection or enzymatic degradation. In the last few decades, a large number of new tetracycline-resistance genes have been discovered in clinical settings. These genes are hypothesized to originate from environmental and commensal bacteria, but the diversity of tetracycline-resistance determinants that have not yet been mobilized into pathogens is unknown. In this study, we aimed to characterize the potential tetracycline resistome by screening genomic and metagenomic data for novel resistance genes. By using probabilistic models, we predicted 125

SUBMITTER: Berglund F 

PROVIDER: S-EPMC7725328 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature