The relationship of 25-hydroxyvitamin D values and risk of fracture: a population-based retrospective cohort study.

ABSTRACT: Our study investigates 25-hydroxyvitamin D levels and fracture risk using population-level data. 25-Hydroxyvitamin D values < 12, 12-19, and > 50 ng/mL were not associated with increased risk of fractures overall compared with values 20-50 ng/mL. Severely low levels may be associated with increased risk of osteoporotic fracture, particularly of the wrist.

Introduction

Studies of the relationship between serum 25-hydroxyvitamin D (25(OH)D) levels and fracture risk have been inconsistent. We hypothesized that high 25(OH)D concentrations (> 50 ng/mL) would be associated with increased risk of fracture.

Methods

We identified all adult patients living in Olmsted County, Minnesota, between January 1, 2005 and December 31, 2011, who had at least one 25(OH)D measurement. Fracture out

SUBMITTER: Aul AJ 

PROVIDER: S-EPMC7725389 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature