Aerolysin nanopores decode digital information stored in tailored macromolecular analytes.

ABSTRACT: Digital data storage is a growing need for our society and finding alternative solutions than those based on silicon or magnetic tapes is a challenge in the era of "big data." The recent development of polymers that can store information at the molecular level has opened up new opportunities for ultrahigh density data storage, long-term archival, anticounterfeiting systems, and molecular cryptography. However, synthetic informational polymers are so far only deciphered by tandem mass spectrometry. In comparison, nanopore technology can be faster, cheaper, nondestructive and provide detection at the single-molecule level; moreover, it can be massively parallelized and miniaturized in portable devices. Here, we demonstrate the ability of engineered aerolysin nanopores to accurately read, wit

SUBMITTER: Cao C 

PROVIDER: S-EPMC7725454 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature