Environmental exposure enhances the internalization of microplastic particles into cells.

ABSTRACT: Microplastic particles ubiquitously found in the environment are ingested by a huge variety of organisms. Subsequently, microplastic particles can translocate from the gastrointestinal tract into the tissues likely by cellular internalization. The reason for cellular internalization is unknown, since this has only been shown for specifically surface-functionalized particles. We show that environmentally exposed microplastic particles were internalized significantly more often than pristine microplastic particles into macrophages. We identified biomolecules forming an eco-corona on the surface of microplastic particles, suggesting that environmental exposure promotes the cellular internalization of microplastics. Our findings further indicate that cellular internalization is a key route by

SUBMITTER: Ramsperger AFRM 

PROVIDER: S-EPMC7725476 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature