Characterization and regulation of osteoclast precursors following chronic Porphyromonas gingivalis infection.

ABSTRACT: Bone destruction in inflammatory osteolytic diseases including periodontitis is related to excessive activity of osteoclasts (OC), which originate from precursor cells of the myeloid lineage, termed osteoclast precursors (OCP). In contrast to ample knowledge that we currently have on mature OC, little is known about OCP and their regulation during bacterial infection. Therefore, this study aimed to identify and characterize OCP following chronic infection with a periodontal bacteria Porphyromonas gingivalis (Pg). We used a micro-osmotic pump to continually release Pg subcutaneously in a murine model. Two weeks after Pg infection, the frequency of CD11b⁺c-fms⁺Ly6C^hi population is significantly elevated within the bone marrow, sple

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC7725479 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature