Exploring the Antihyperglycemic Chemical Composition and Mechanisms of Tea Using Molecular Docking.

ABSTRACT: Tea, a widely consumed beverage, has long been utilized for promoting human health with a close correlation to hyperglycemia. The Tea Metabolome Database (TMDB), the most complete and comprehensive curated collection of tea compounds data containing 1271 identified small molecule compounds from the tea plant (Camellia sinensis), was established previously by our research team. More recently, our studies have found that various tea types possess an antihyperglycemic effect in mice. However, the bioactive ingredients from tea have potential antihyperglycemic activity and their underlying molecular mechanisms remain unclear. In this study, we used a molecular docking approach to investigate the potential interactions between a selected 747 constituents contained in tea and 11 key prote

SUBMITTER: Sun Y 

PROVIDER: S-EPMC7725569 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature