Radix Rehmanniae and Corni Fructus against Diabetic Nephropathy via AGE-RAGE Signaling Pathway.

ABSTRACT:

Background and aims

Radix Rehmanniae and Corni Fructus (RC) have been widely applied to treat diabetic nephropathy (DN) for centuries. But the mechanism of how RC plays the therapeutic role against DN is unclear as yet.

Methods

The information about RC was obtained from a public database. The active compounds of RC were screened by oral bioavailability (OB) and drug-likeness (DL). Gene ontology (GO) analysis was performed to realize the key targets of RC, and an active compound-potential target network was created. The therapeutic effects of RC active compounds and their key signal pathways were preliminarily probed via network pharmacology analysis and animal experiments.

Results

In this study, 29 active compounds from RC and 64 key targets related to DN were collect

SUBMITTER: Chen J 

PROVIDER: S-EPMC7725584 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature