Informing epidemic (research) responses in a timely fashion by knowledge management - a Zika virus use case.

ABSTRACT: The response of pathophysiological research to emerging epidemics often occurs after the epidemic and, as a consequence, has little to no impact on improving patient outcomes or on developing high-quality evidence to inform clinical management strategies during the epidemic. Rapid and informed guidance of epidemic (research) responses to severe infectious disease outbreaks requires quick compilation and integration of existing pathophysiological knowledge. As a case study we chose the Zika virus (ZIKV) outbreak that started in 2015 to develop a proof-of-concept knowledge repository. To extract data from available sources and build a computationally tractable and comprehensive molecular interaction map we applied generic knowledge management software for literature mining, expert knowledge

SUBMITTER: Bauch A 

PROVIDER: S-EPMC7725600 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature