The interplay of dissolution, solution crystallization and solid-state transformation of amorphous indomethacin in aqueous solution.

ABSTRACT: Supersaturation profiles of amorphous indomethacin in aqueous solution containing 0.4 wt% and 4 wt% of isopropanol were predicted by combining separately-determined kinetics for dissolution, solution crystallization, and solid-state transformation. The kinetics of solid-state transformation were measured and compared to various data from the literature. The proposed kinetic model accounts for dissolution, solution crystallization and amorphous-to-crystalline solid-state transformation. It was validated for different initial amounts of amorphous and crystalline material and systems with different isopropanol contents. Furthermore, the influence of polyethylene glycol on the supersaturation behavior was investigated. The results clearly show the robustness of the model and give insight into

SUBMITTER: Schneider R 

PROVIDER: S-EPMC7725739 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature