Ontology highlight
ABSTRACT:
SUBMITTER: Tai-Nagara I
PROVIDER: S-EPMC7725783 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Nature communications 20201209 1
Blood and lymphatic vessels structurally bear a strong resemblance but never share a lumen, thus maintaining their distinct functions. Although lymphatic vessels initially arise from embryonic veins, the molecular mechanism that maintains separation of these two systems has not been elucidated. Here, we show that genetic deficiency of Folliculin, a tumor suppressor, leads to misconnection of blood and lymphatic vessels in mice and humans. Absence of Folliculin results in the appearance of lympha ...[more]