Computational insights into RNAi-based therapeutics for foot and mouth disease of Bos taurus.

ABSTRACT: Foot-and-mouth disease (FMD) endangers a large number of livestock populations across the globe being a highly contagious viral infection in wild and domestic cloven-hoofed animals. It adversely affects the socioeconomic status of millions of households. Vaccination has been used to protect animals against FMD virus (FMDV) to some extent but the effectiveness of available vaccines has been decreased due to high genetic variability in the FMDV genome. Another key aspect that the current vaccines are not favored is they do not provide the ability to differentiate between infected and vaccinated animals. Thus, RNA interference (RNAi) being a potential strategy to control virus replication, has opened up a new avenue for controlling the viral transmission. Hence, an attempt has been made here

SUBMITTER: Sahu TK 

PROVIDER: S-EPMC7725835 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature