Pan-cancer analysis of genomic properties and clinical outcome associated with tumor tertiary lymphoid structure.

ABSTRACT: How the genomic landscape of a tumor shapes the formation of tertiary lymphoid structure (TLS) and how might TLS alter the clinical outcome or response to immunotherapy had not been systematically explored. Utilizing the genomic and transcriptome data of solid tumors on TCGA, we quantified TLS based on a previous identified 12-chemokine signature and evaluated its correlation with mutation/neoantigen burden, functional mutation of oncogenes and the presence of viral infection. Clinical data was integrated to decide the prognostic significance of TLS for different cancers after surgical treatment. Publicly available data (clinical and transcriptome data) of immunotherapy clinical trials involving melanoma and lung cancer were also collected to evaluate TLS's association with therapeutic out

SUBMITTER: Lin Z 

PROVIDER: S-EPMC7725838 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature