PIEZO2 in sensory neurons and urothelial cells coordinates urination.

ABSTRACT: Henry Miller stated that "to relieve a full bladder is one of the great human joys". Urination is critically important in health and ailments of the lower urinary tract cause high pathological burden. Although there have been advances in understanding the central circuitry in the brain that facilitates urination^1-3, there is a lack of in-depth mechanistic insight into the process. In addition to central control, micturition reflexes that govern urination are all initiated by peripheral mechanical stimuli such as bladder stretch and urethral flow⁴. The mechanotransduction molecules and cell types that function as the primary stretch and pressure detectors in the urinary tract mostly remain unknown. Here we identify expression of the mechanosensitive ion channel PIEZO2

SUBMITTER: Marshall KL 

PROVIDER: S-EPMC7725878 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature