Protracted viral shedding and viral load are associated with ICU mortality in Covid-19 patients with acute respiratory failure.

ABSTRACT:

Background

Protracted viral shedding is common in hospitalized patients with COVID-19 pneumonia, and up to 40% display signs of pulmonary fibrosis on computed tomography (CT) after hospital discharge. We hypothesized that COVID-19 patients with acute respiratory failure (ARF) who die in intensive care units (ICU) have a lower viral clearance in the respiratory tract than ICU patients discharged alive, and that protracted viral shedding in respiratory samples is associated with patterns of fibroproliferation on lung CT. We, therefore, conducted a retrospective observational study, in 2 ICU of Lyon university hospital.

Results

129 patients were included in the study, of whom 44 (34%) died in ICU. 432 RT-PCR for SARS-CoV-2 were performed and 137 CT scans were analyzed. Viral lo

SUBMITTER: Bitker L 

PROVIDER: S-EPMC7725883 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature