Factors that impact fragility index and their visualizations.

ABSTRACT:

Rationale aims and objectives

As the recent literature has growing concerns about research replicability and the misuse and misconception of P-values, the fragility index (FI) has been an attractive measure to assess the robustness (or fragility) of clinical study results with binary outcomes. It is defined as the minimum number of event status modifications that can alter a study result's statistical significance (or non-significance). Owing to its intuitive concept, the FI has been applied to assess the fragility of clinical studies of various specialties. However, the FI may be limited in certain settings. As a relatively new measure, more work is needed to examine its properties.

Methods

This article explores several factors that may impact the derivation of the FI, incl

SUBMITTER: Lin L 

PROVIDER: S-EPMC7725889 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature