Enantioconvergent Amination of Racemic Tertiary C-H Bonds.

ABSTRACT: Racemization is considered to be an intrinsic stereochemical feature of free radical chemistry as can be seen in traditional radical halogenation reactions of optically active tertiary C-H bonds. If the facile process of radical racemization could be effectively combined with an ensuing step of bond formation in an enantioselective fashion, then it would give rise to deracemizative functionalization of racemic tertiary C-H bonds for stereoselective construction of chiral molecules bearing quaternary stereocenters. As a demonstration of this unique potential in radical chemistry, we herein report that metalloradical catalysis can be successfully applied to devise Co(II)-based catalytic system for enantioconvergent radical amination of racemic tertiary C(sp³)-H bonds. The key to t

SUBMITTER: Lang K 

PROVIDER: S-EPMC7725894 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature