Sex-related Differences in Tau Positron Emission Tomography (PET) and the Effects of Hormone Therapy (HT).

ABSTRACT:

Importance

Female sex is a major risk factor for late-onset Alzheimer disease (AD), and sex hormones have been implicated as a possible protective factor. Neuroimaging studies that evaluated the effects of sex hormones on brain integrity have primarily emphasized neurodegenerative measures rather than amyloid and tau burden.

Objective

We compared cortical amyloid and regional tau positron emission tomography (PET) deposition between cognitively normal males and females. We also compared preclinical AD pathology between females who have and have not used hormone therapy (HT). Finally, we compared the effects of amyloid and tau pathology on cognition, testing for both sex and HT effects.

Design, setting, and participants

We analyzed amyloid, tau, and cognition in a cogn

SUBMITTER: Wisch JK 

PROVIDER: S-EPMC7725985 | biostudies-literature | 2021 Apr-Jun 01

REPOSITORIES: biostudies-literature