IL-18 Responsiveness Defines Limitations in Immune Help for Specialized FcRγ^- NK Cells.

ABSTRACT: Despite being prolific innate killers, NK cells are also key helper cells in antiviral defense, influencing adaptive immune responses via interactions with dendritic cells (DCs). In addition to causing NK cell dysfunction, HIV-1 infection contributes to the expansion of a rare population of NK cells deficient in FcRγ (FcRγ^-), an intracellular adaptor protein that associates with CD16. The implications of this inflated NK cell subset in treated HIV-1 infection remain unclear. In this study, we explored the helper function of human NK cells in chronic HIV-1 infection, with a particular focus on characterizing FcRγ^- NK cells. Exposure of NK cells to innate DC-derived costimulatory factors triggered their helper activity, defined by their ability to produce IFN-γ and to d

SUBMITTER: Anderko RR 

PROVIDER: S-EPMC7725987 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature