Tunable dynamics of B cell selection in gut germinal centres.

ABSTRACT: Germinal centres, the structures in which B cells evolve to produce antibodies with high affinity for various antigens, usually form transiently in lymphoid organs in response to infection or immunization. In lymphoid organs associated with the gut, however, germinal centres are chronically present. These gut-associated germinal centres can support targeted antibody responses to gut infections and immunization¹. But whether B cell selection and antibody affinity maturation take place in the face of the chronic and diverse antigenic stimulation characteristic of these structures under steady state is less clear^2-8. Here, by combining multicolour 'Brainbow' cell-fate mapping and sequencing of immunoglobulin genes from single cells, we find that 5-10% of gut-associated g

SUBMITTER: Nowosad CR 

PROVIDER: S-EPMC7726069 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature