The Influence of Axial Length Upon the Retinal Ganglion Cell Layer of the Human Eye.

ABSTRACT:

Purpose

Variation in retinal thickness with eye size complicates efforts to estimate retinal ganglion cell number from optical coherence tomography (OCT) measures. We examined the relationship among axial length, the thickness and volume of the ganglion cell layer (GCL), and the size of the optic chiasm.

Methods

We used OCT to measure GCL thickness over 50 degrees of the horizontal meridian in 50 healthy participants with a wide range of axial lengths. Using a model eye informed by individual biometry, we converted GCL thickness to tissue volume per square degree. We also measured the volume of the optic chiasm for 40 participants using magnetic resonance imaging (MRI).

Results

There is a positive relationship between GCL tissue volume and axial length. Given prior ps

SUBMITTER: Chen M 

PROVIDER: S-EPMC7726585 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature