Ontology highlight
ABSTRACT:
SUBMITTER: Veliova M
PROVIDER: S-EPMC7726774 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Veliova Michaela M Ferreira Caroline M CM Benador Ilan Y IY Jones Anthony E AE Mahdaviani Kiana K Brownstein Alexandra J AJ Desousa Brandon R BR Acín-Pérez Rebeca R Petcherski Anton A Assali Essam A EA Stiles Linsey L Divakaruni Ajit S AS Prentki Marc M Corkey Barbara E BE Liesa Marc M Oliveira Marcus F MF Shirihai Orian S OS
EMBO reports 20201204 12
Combined fatty acid esterification and lipolysis, termed lipid cycling, is an ATP-consuming process that contributes to energy expenditure. Therefore, interventions that stimulate energy expenditure through lipid cycling are of great interest. Here we find that pharmacological and genetic inhibition of the mitochondrial pyruvate carrier (MPC) in brown adipocytes activates lipid cycling and energy expenditure, even in the absence of adrenergic stimulation. We show that the resulting increase in A ...[more]