Transcriptome profiling revealed early vascular smooth muscle cell gene activation following focal ischemic stroke in female rats - comparisons with males.

ABSTRACT:

Background

Women account for 60% of all stroke deaths and are more often permanently disabled than men, despite their higher observed stroke incidence. Considering the clinical population affected by stroke, an obvious drawback is that many pre-clinical and clinical studies only investigate young males. To improve therapeutic translation from bench to bedside, we believe that it is advantageous to include both sexes in experimental models of stroke. The aims of this study were to identify early cerebral vascular responses to ischemic stroke in females, compare the differential gene expression patterns with those seen in males, and identify potential new therapeutic targets.

Results

Transient middle cerebral artery occlusion (tMCAO) was used to induce stroke in both female an

SUBMITTER: Rehnstrom M 

PROVIDER: S-EPMC7726885 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature