Experimental and Computational Investigations of Carboplatin Supramolecular Complexes.

ABSTRACT: Supramolecular systems (macromolecules), such as calix[n]arenes (SCn), cyclodextrins (CDs), and cucurbiturils (CBs), are promising vehicles for anticancer drugs. In this work, guest-host complexes of carboplatin, a second-generation platinum-based anticancer drug, and p-4-sulfocalix[n]arenes (n = 4 and 6; PS4 and PS6, respectively) were prepared and studied using ¹H NMR, UV, Job's plot analysis, HPLC, and density-functional theory calculations. The experimental and the computational studies suggest the formation of 1:1 complexes between carboplatin and each of PS4 and PS6. The stability constants of the formed complexes were estimated to be 5.3 × 10⁴ M^-1 and 9.8 × 10⁴ M^-1, which correspond to free energy of complex

SUBMITTER: Fahmy SA 

PROVIDER: S-EPMC7726934 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature