Transcriptomic profiles in pulmonary arterial hypertension associate with disease severity and identify novel candidate genes.
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ABSTRACT:
SUBMITTER: Romanoski CE
PROVIDER: S-EPMC7727059 | biostudies-literature | 2020 Oct-Dec
REPOSITORIES: biostudies-literature
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Transcriptomic profiles in pulmonary arterial hypertension associate with disease severity and identify novel candidate genes.
Romanoski Casey E CE Qi Xinshuai X Sangam Shreya S Vanderpool Rebecca R RR Stearman Robert S RS Conklin Austin A Gonzalez-Garay Manuel M Rischard Franz F Ayon Ramon J RJ Wang Jian J Simonson Tatum T Babicheva Aleksandra A Shi Yinan Y Tang Haiyang H Makino Ayako A Kanthi Yogendra Y Geraci Mark W MW Garcia Joe G N JGN Yuan Jason X-J JX Desai Ankit A AA
Pulmonary circulation 20201001 4
Using RNAseq, we identified a 61 gene-based circulating transcriptomic profile most correlated with four indices of pulmonary arterial hypertension severity. In an independent dataset, 13/61 (21%) genes were differentially expressed in lung tissues of pulmonary arterial hypertension cases versus controls, highlighting potentially novel candidate genes involved in pulmonary arterial hypertension development. ...[more]
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