Transcriptomic profiles in pulmonary arterial hypertension associate with disease severity and identify novel candidate genes.

ABSTRACT: Using RNAseq, we identified a 61 gene-based circulating transcriptomic profile most correlated with four indices of pulmonary arterial hypertension severity. In an independent dataset, 13/61 (21%) genes were differentially expressed in lung tissues of pulmonary arterial hypertension cases versus controls, highlighting potentially novel candidate genes involved in pulmonary arterial hypertension development.

SUBMITTER: Romanoski CE 

PROVIDER: S-EPMC7727059 | biostudies-literature | 2020 Oct-Dec

REPOSITORIES: biostudies-literature